Uniform Laser Nomenclature Establishes Therapy Classification System

A uniform laser nomenclature can enable a better understanding of laser and light therapies, according to presenters at the Association for Research and Vision in Ophthalmology (ARVO) Annual Meeting in New Orleans, on April 23–27, 2023. A team of investigators have developed a research-informed nomenclature for non-destructive phototherapy techniques. This classification creates a uniform structure for the many laser modes, dosing regimens, and treatments emerging without a standardized organizing taxonomy.

Regenerative phototherapies classified in the uniform laser nomenclature include lasers or other lights that treat the retinal pigment epithelium (RPE), choroid, and photoreceptor complex without leaving damage. Investigators conducted a systematic literature review of applicable macular treatments, as well as interviews with practicing professionals and retina experts. 

Centered on overall therapeutic goals, researchers recommend a title for the uniform laser nomenclature system that will advance the various approaches; “retina regenerative laser and light therapies (RELITE).” Four main subcategories characterize physical and biochemical change expected, as well as 3-letter codes indicating distinctive photo techniques. A suggested working formula is; pattern, irradiation, dosing, subcategory, category. Delivery methods are organized by mechanism of action.

Subcategory 1 is based on temperature increase — photothermal laser therapy (PTL). The second subcategory comprises RPE rejuvenation, and is designated photo-disruptive laser therapy (PDL). The photochemical processes in subcategory 3 are termed photochemical laser therapy (PCL), and the fourth group, photobiological modulations, is classified as photobiological light therapy (PBL).

Specific irradiation technique codes in the first PTL subcategory include microsecond laser therapy (MLT), nondamaging retinal therapy (NRT), thermal stimulation of the retina (TSR), and transpupillary thermal therapy (TTT). Two specific 3-letter designations for PDL methods involve retinal rejuvenation therapy (2RT) and selective retina therapy (SRT). PCL incorporates the 3-letter code classifying photodynamic therapy (PDT); and the PBL subcategory the code for retinal photo-biomodulation (PBM). The uniform laser nomenclature also identifies an abundance of technical specifications, the researchers explain.

“A precise nomenclature system and strict reporting standards are needed to allow for a better understanding, reproduceable comparable clinical trials and overall acceptance,” according to the study.

Disclosures: Some study authors declared affiliations with the biotech, pharmaceutical, and/or medical device companies. Please see the original reference for a full list of authors’ disclosures.