Diabetic Retinopathy The Most Common Comorbidity in Central Serous Chorioretinopathy

01B0V9QT – Fundoscopy showing birdshot retinochoroidopathy (chronic posterior uveitis, an inflammation of the uvea of the eye). Also known as birdshot chorioretinopathy, this rare inflammatory eye disorder is marked by small light-colored spots on theretina, scattered in a pattern like birdshot from a shotgun . It is suspected to be an autoimmune disease. (c) Sovereign
Common ocular association can provide information clinicians can use to strategize treatment approaches.

Researchers estimate a 6.32% prevalence of additional ocular comorbidities in patients with central serous chorioretinopathy (CSCR), with diabetic retinopathy (DR) being most common, according to findings presented at the American Society of Retina Specialists 40th Annual Meeting, held in New York July 13-16, 2022.

The researchers conducted a retrospective, multicentric, cross-sectional, observational study. Data from patients with a diagnosis of CSCR between January 2016 and December 2020 were acquired from 5 centers in India, Russia, and the United States. The team reviewed the charts and classified other ocular comorbidities based on ICD-9 codes. They also used data from patients’ initial comprehensive ophthalmic evaluation, including medical history, best-corrected visual acuity (BCVA), measurement of intraocular pressure, and anterior segment slit-lamp biomicroscopy along with dilated fundus examination.

Of 9157 total patients, 579 (6.32%) patients (766 eyes) had a diagnosis of CSCR and other ocular comorbidity. Macular ocular comorbidities included DR (18.14%; BCVA, 0.49), non-exudative age-related macular degeneration (3.39%; BCVA, 0.75), and hypertensive retinopathy (2.35%; BCVA, 0.74) and had an average VA of 0.50 logMAR. Nonmacular ocular comorbidities included optic atrophy (2.48%; BCVA, 0.30), rhegmatogenous retinal detachment (1.70%; BCVA, 0.41), and optic disc pit (1.44%; BCVA, 0.45) and had an average VA of 0.55 logMAR. 

The researchers observed increased odds of having CSCR with peripheral pigmentary changes (odds ratio [OR], 2.72; P =.03), branch retinal vein occlusion (OR, 2.6; P=.05), and Vogt-Koyanagi-Harada disease (OR, 6.22; P =.05).

“Knowing prevalence of comorbid ocular disease in eyes with CSCR can be important in both timely diagnosis appropriate treatment in these patients,” concluded the authors.

Disclosure: One study author declared affiliations with biotech, pharmaceutical, and/or device companies. Please see the original reference for a full list of authors’ disclosures.  


Samanta A, Driban M, Sahoo N, et al. Central serous chorioretinopathy and ocular comorbidities. Poster presented at: The 40th annual meeting of the American Society of Retina Specialists (ASRS); July 13-16, 2022; New York. Presentation 229.