IVIG, Anti-Inflammatory Therapies Can Reduce Cataract Surgery Complications

Eye of patient during the cataract surgery.
A preoperative protocol may limit complications of cataract surgery for patients with existing graft vs host disease.

This article is part of Ophthalmology Advisor’s Dry Eye Disease In-Depth coverage from the 2021 meeting of the American Academy of Ophthalmology, held in New Orleans from November 12 to 15, 2021. The team at Ophthalmology Advisor will be reporting on a variety of the research presented by the dry eye disease experts at the AAO. Check back for more from the AAO 2021 Meeting.


Ocular graft vs host disease can lead to complications in patients undergoing cataract surgery. But a novel therapeutic approach may help prevent these complications and ensure a successful cataract removal, according to presenters at the American Academy of Ophthalmology 2021 meeting, held in New Orleans, November 12-15. 

The presenters reviewed a study into the preoperative use of topical pooled immunoglobulin drops (IVIG), combined with serum tears and topical preservative-free methylprednisolone. No punctual occlusion was included in the protocol. 

Researchers looked into 35 cataract surgeries for 20 patients. The average follow-up time was 8 months after the surgery and researchers considered visual acuities the primary outcome measurements. They were assessed at 1 week, 1 month, 6 months, and at final follow-up. Additionally, researchers gathered Ocular Surface Disease Index (OSDI) scores, lissamine green staining, and noted complications, all of which were compared to data from the literature. 

Data from this study supports that using this novel preoperative protocol to minimize inflammation has significant benefits in diminishing post operative complications.  

Visit Ophthalmology Advisor’s conference section for the complete Dry Eye Disease coverage from the AAO 2021.



Roca D, de la Cruz Napoli JJ , Jain J, Shorter E. Novel management of inflammation in patients with ocular gvhd in the setting of cataract surgery. Paper presented at: The American Academy of Ophthalmology 2021 Annual Meeting; November 12-15, 2021; New Orleans. PA030.