Are You Confident of the Diagnosis? What you should be alert for in the history Superficial acral fibromyxoma (SAF) presents as a slow-growing solitary tumor that typically arises on the hands and feet, with a predilection for the periungual region of fingers and toes. The tumors are frequently asymptomatic, but may be uncomfortable with pressure…
Are You Confident of the Diagnosis? POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) is a paraneoplastic syndrome that is associated with an underlying plasma cell dyscrasia. It typically presents with an initially distal but progressive ascending symmetric sensory and motor neuropathy, accompanied by a variety of other systemic signs and symptoms, and laboratory…
Are You Confident of the Diagnosis? What you should be alert for in the history Glomeruloid hemangioma is a rare benign cutaneous vascular proliferation that typically arises in patients with a history of POEMS syndrome, a paraneoplastic syndrome associated with a plasma cell proliferative disorder. The POEMS acronym stands for polyneuropathy, organomegaly, endocrinopathy, M-protein, and…
